Isoamylamine → HCID 11754033, compound

HRID 1391422Notes

Reaction equation

HRID 1391422 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:31]=[CH:30][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25]NCCC)=[CH:21][CH:20]=3)=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH2:32]([NH2:37])[CH2:33][CH:34]([CH3:36])[CH3:35]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]([O:14][CH2:15][CH2:16][NH:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([CH2:25][NH:37][CH2:32][CH2:33][CH:34]([CH3:36])[CH3:35])=[CH:23][CH:24]=3)=[CH:30][CH:31]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7894IsoamylamineHCID 10094381HCID 10094381, compound

Product 1

HCID 11754033HCID 11754033, compound

Procedure

Compound 5 was synthesized using the procedure described for Compound 2 except that isoamylamine was used in the final reductive amination step. Compound 5 was obtained as a white solid. MS 462; 1H NMR (CDCl3) δ 4.10 (t, 2H), 3.86 (s, 2H), 3.77 (s, 2H), 3.03 (t, 2H), 2.63 (t, 2H), 0.89 (d, 6H).

Workup

  1. customCompound 5 was synthesized

Sources & evidence

ORD record
ord-8939b0352c624e01af0a2e61e86f4dd1
Source dataset
uspto-grants-2008_03
Patent number
US07338952B2

Reaction notes

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