HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1391439Generated: October 30, 2026
Tetrabutylammonium Fluoride → (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-S-cyclopropylsulfoximide
https://huagongshe.com/reaction/1391439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]-pyrimidin-2-yl}amino)phenyl]-S-cyclopropyl-N-[2-(trimethylsilyl)ethylsulfonyl]-sulfoximide | HCID 59674047 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]pyrimidin-2-yl}amino)phenyl]-S-cyclopropylsulfoximide | HCID 59674027 | — |
Reaction Steps
50 mg of (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]-pyrimidin-2-yl}amino)phenyl]-S-cyclopropyl-N-[2-(trimethylsilyl)ethylsulfonyl]-sulfoximide is dissolved in 1 ml of tetrahydrofuran and mixed with 0.3 ml of a 1 M solution of tetrabutylammonium fluoride in tetrahydrofuran. The mixture is stirred for 3 days at 50° C. and purified by flash chromatography (dichloromethane-dichloromethane/ethanol 9:1). 10 mg (28% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07338958B2 |
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| Source dataset | uspto-grants-2008_03 |
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| ORD ID | ord-baa6d63d296b48bd85caaba639f8ad39 |
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| Source note | uspto-grants-2008_03 |
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