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HRID1391439

反应详情

EQUATION

反应方程式

HRID 1391439 的结构方程式

REACTANTS

反应物

2
结构：CCCC[N+](CCCC)(CCCC)CCCC.[F-]
HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：C[C@@H](Nc1nc(Nc2ccc(S(=O)(=NS(=O)(=O)CC[Si](C)(C)C)C3CC3)cc2)ncc1Br)C(C)(C)O
HCID59674047

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](Nc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1Br)C(C)(C)O
HCID59674027

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

50 mg of (RS)-S-[4-({5-bromo-4-[(R)-(2-hydroxy-1,2-dimethylpropyl)amino]-pyrimidin-2-yl}amino)phenyl]-S-cyclopropyl-N-[2-(trimethylsilyl)ethylsulfonyl]-sulfoximide is dissolved in 1 ml of tetrahydrofuran and mixed with 0.3 ml of a 1 M solution of tetrabutylammonium fluoride in tetrahydrofuran. The mixture is stirred for 3 days at 50° C. and purified by flash chromatography (dichloromethane-dichloromethane/ethanol 9:1). 10 mg (28% of theory) of the product is obtained.

WORKUP

后处理

  1. custompurified by flash chromatography (dichloromethane-dichloromethane/ethanol 9:1)
  2. custom10 mg (28% of theory) of the product is obtained