反应详情

1.77 g (4.6 mmol) of 5-bromo-N4-isopropyl-N2-[4-(methylsulfanyl)phenyl)-pyrimidine-2,4-diamine hydrochloride is taken up in 40 ml of DCM and mixed with 1.73 g (5.5 mmol) of 3-chloroperoxybenzoic acid (55%). The batch is stirred for 90 minutes at room temperature and then diluted with DCM. It is washed with saturated NaHCO3 solution and saturated NaCl solution. The organic phase is dried (Na2SO4), filtered and concentrated by evaporation. The remaining residue is purified by chromatography (DCM/EtOH 9:1). 553 mg (1.5 mmol, corresponding to 33% of theory) of the product is obtained.

1. washIt is washed with saturated NaHCO3 solution and saturated NaCl solution
2. dry with materialThe organic phase is dried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated by evaporation
5. customThe remaining residue is purified by chromatography (DCM/EtOH 9:1)
6. custom553 mg (1.5 mmol, corresponding to 33% of theory) of the product is obtained