反应详情

1 g of potassium hydroxide is dissolved in 40 ml of methanol and mixed with 2.3 g of 4-nitrothiophenol. The suspension is stirred for one hour at room temperature and mixed drop by drop with 1.48 ml of 1-bromo-3-chloropropane. After 4 hours of stirring at room temperature, another 0.15 ml of 1-bromo-3-chloropropane is added in drops. The mixture is stirred for 65 hours at room temperature, concentrated by evaporation in a vacuum and taken up in ethyl acetate. It is extracted with water and saturated common salt solution, dried on sodium sulfate and concentrated by evaporation. After purification by flash chromatography, 2.54 g of 1-(3-chloro-propylsulfanyl)-4-nitro-benzene is obtained.

1. stirringAfter 4 hours of stirring at room temperature
2. stirringThe mixture is stirred for 65 hours at room temperature
3. concentrationconcentrated by evaporation in a vacuum
4. extractionIt is extracted with water and saturated common salt solution
5. customdried on sodium sulfate
6. concentrationconcentrated by evaporation
7. customAfter purification by flash chromatography