3-(Morpholine-4-sulfonyl)aniline → 2-N-(5-tert-butyl-1,2-oxazol-3-yl)-1-methyl-5-N-[2-(3-morpholin-4-ylsulfonylanilino)pyrimidin-4-yl]benzimidazole-2,5-diamine

HRID 1391632Notes

Reaction equation

HRID 1391632 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]2[N:15]([CH3:16])[C:14]3[CH:17]=[CH:18][C:19]([NH:21][C:22]4[CH:27]=[CH:26][N:25]=[C:24](Cl)[N:23]=4)=[CH:20][C:13]=3[N:12]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N:29]1([S:35]([C:38]2[CH:39]=[C:40]([NH2:44])[CH:41]=[CH:42][CH:43]=2)(=[O:37])=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]2[N:15]([CH3:16])[C:14]3[CH:17]=[CH:18][C:19]([NH:21][C:22]4[CH:27]=[CH:26][N:25]=[C:24]([NH:44][C:40]5[CH:41]=[CH:42][CH:43]=[C:38]([S:35]([N:29]6[CH2:34][CH2:33][O:32][CH2:31][CH2:30]6)(=[O:37])=[O:36])[CH:39]=5)[N:23]=4)=[CH:20][C:13]=3[N:12]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 5594103-(Morpholine-4-sulfonyl)anilineHCID 91543477N2-(5-tert-Butyl-isoxazol-3-yl)-N5-(2-chloro-pyrimidin-4-yl)-1-methyl-1H benzoimidazole-2,5-diamine

Product 1

HCID 445267362-N-(5-tert-butyl-1,2-oxazol-3-yl)-1-methyl-5-N-[2-(3-morpholin-4-ylsulfonylanilino)pyrimidin-4-yl]benzimidazole-2,5-diamine

Procedure

The title compound was prepared following the procedure of Example I with N2-(5-tert-Butyl-isoxazol-3-yl)-N5-(2-chloro-pyrimidin-4-yl)-1-methyl-1H benzoimidazole-2,5-diamine (35 mg, 0.09 mmol) and 3-(Morpholine-4-sulfonyl)-phenylamine (23 mg, 0.10 mmol) to afford an off white solid (32 mg, 005. mmol). MS (ESI) m/z=605 [M+H]+.

Workup

  1. customto afford an off white solid (32 mg, 005. mmol)

Sources & evidence

ORD record
ord-adc4ebe4b72f46678a1f8465137ad006
Source dataset
uspto-grants-2008_03
Patent number
US07338959B2

Reaction notes

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