反应详情

温度

35 °C

To a solution of methyl 5,5-dimethyl-5,6-dihydro-8-(2-thienyl)-2-naphthalenecarboxylate (Compound E5, 430.0 mg, 1.44 mmol) in 3.0 mL of EtOH and 3.0 mL THF was added NaOH (240.0 mg, 6.00 mmol; 3.0 mL of a 2N aqueous solution). The resulting solution was warmed to 35° C. for 6 h, cooled to room temperature and quenched with 1M HCl. The mixture was extracted with EtOAc and the combined organic layers washed with H2O and saturated aqueous NaCl before being dried over MgSO4. Removal of the solvents under reduced pressure afforded the title compound as a pale yellow solid.

1. temperaturecooled to room temperature
2. customquenched with 1M HCl
3. extractionThe mixture was extracted with EtOAc
4. washthe combined organic layers washed with H2O and saturated aqueous NaCl
5. dry with materialbefore being dried over MgSO4
6. customRemoval of the solvents under reduced pressure