反应详情

To a solution of (S)-N-benzyl-1-phenylprop-2-en-1-amine (5a) (240 mg) in DCM (5 mL) at RT under N2 was added (2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pent-4-enoic acid (4b) (263 mg) and EDAC.HCl (224 mg). The mixture was stirred overnight at RT, then diluted with 30% hexanes/EtOAc and washed with H2O, 0.2 N HCl, saturated NaHCO3, brine, dried (Na2SO4), filtered, and concentrated to a white foamy solid (233 mg, 48%). 1H NMR (300 MHz) The NMR of this compound in both CDCl3 and DMSO-d6 (with elavated temperatures) was complex, thus limiting interpretation. MS APCI, m/z=451 (M+1). LC/MS 3.13 min., Method A.

1. washwashed with H2O, 0.2 N HCl, saturated NaHCO3, brine
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. concentrationconcentrated to a white foamy solid (233 mg, 48%)
5. customLC/MS 3.13 min., Method A