Acetic Acid → HCID 22719718, compound

HRID 1392141Notes

Reaction equation

HRID 1392141 reaction equation
C([S:4][CH2:5][CH:6]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])(=O)C.[OH2:21].[Cl-:22].C(O)(=[O:25])C>>[Cl:22][S:4]([CH2:5][CH:6]([CH2:17][CH:18]([CH3:20])[CH3:19])[C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])(=[O:25])=[O:21]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 312ChlorideHCID 962WaterHCID 22719690HCID 22719690, compound

Product 1

HCID 22719718HCID 22719718, compound

Procedure

A solution of benzyl 3-acetylthio-2-isobutylpropionate (588 mg, 2 mmol) in acetic acid (12 ml)-water (1.6 ml) at 0° C. was reacted with gaseous chloride (prealably condensed at −78° C., 1.9 ml). After chlorine had distilled, the solvents are evaporated in vacuo to give crude benzyl 3-chlorosulfonyl-2-isobutylpropionate (630 mg).

Workup

  1. customprealably condensed at −78° C.
  2. distillationAfter chlorine had distilled
  3. customthe solvents are evaporated in vacuo

Sources & evidence

ORD record
ord-6cdfce0a7ca84e079176d6947dc679d8
Source dataset
uspto-grants-2008_03
Patent number
US07342020B2

Reaction notes

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