HCID 22719692, compound → HCID 22719714, compound

HRID 1392142Notes

Reaction equation

HRID 1392142 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([S:14]([CH2:17][CH:18]([CH2:29][CH:30]([CH3:32])[CH3:31])[C:19]([O:21]CC3C=CC=CC=3)=[O:20])(=[O:16])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>CO.[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([S:14]([CH2:17][CH:18]([CH2:29][CH:30]([CH3:32])[CH3:31])[C:19]([OH:21])=[O:20])(=[O:16])=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 22719692HCID 22719692, compound

Product 1

HCID 22719714HCID 22719714, compoundYield 90.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 3-[4-(4-fluorophenyl)piperazine-1-sulfonyl]-2-isobutylpropionate (630 mg) in methanol (10 ml) was hydrogenated under 40 PSI pressure for 18 hours in the presence of palladium on charcoal (63 mg, 10%). The catalyst was removed by filtration and the solvents were removed in vacuo to give 3-[4(4-fluorophenyl)piperazine-1-sulfonyl]-2-isobutylpropionic acid (460 mg).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-67147d5c643041f6aaf39c9ba54b8ef3
Source dataset
uspto-grants-2008_03
Patent number
US07342020B2

Reaction notes

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