反应详情

A solution of 2-(4-chloromethyl-oxazol-2-yl)-5-trifluoromethoxy-1H-indole (0.3 g, 0.95 mmol) and 4-bromo-benzenesulfinic acid sodium salt (0.92 g, 3.8 mmol) in N,N-dimethyl formamide (10 ml) was stirred for 16 h at 60° C. After cooling the mixture was poured on water (20 ml) and extracted with ethyl acetate (3×20 ml). The combined organic extracts were dried over sodium sulfate and concentrated in vacuo. Chromatography on silica gel (ethyl acetate/iso-hexanes 1:1) yielded the title compound as tan solid. Yield 0.28 g (59%)

1. temperatureAfter cooling the mixture
2. additionwas poured on water (20 ml)
3. extractionextracted with ethyl acetate (3×20 ml)
4. dry with materialThe combined organic extracts were dried over sodium sulfate
5. concentrationconcentrated in vacuo