Bromine → 2-Bromo-2-(4-bromophenyl)-1-(2,4-dichlorophenyl)ethanone

HRID 1392366Notes

Reaction equation

HRID 1392366 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])=[O:10])=[CH:4][CH:3]=1.[Br:19]Br>C1C=CC=CC=1>[Br:19][CH:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=1[Cl:18])=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 634923632-(4-Bromophenyl)-1-(2,4-dichlorophenyl)ethanone

Product 1

HCID 877685312-Bromo-2-(4-bromophenyl)-1-(2,4-dichlorophenyl)ethanoneYield 94%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Part C: To a solution of 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)ethanone (5.00 gram, 15 mmol) in benzene (50 mL) is dropwise added bromine (0.75 mL, 15 mmol) and the resulting solution is stirred for 4 hours at room temperature and concentrated in vacuo. Dichloromethane is added and the resulting solution is washed with brine, dried over MgSO4, filtered and concentrated in vacuo to give 2-bromo-2-(4-bromophenyl)-1-(2,4-dichlorophenyl)ethanone as an oil (5.96 gram, 94% yield).

Workup

  1. concentrationconcentrated in vacuo
  2. additionDichloromethane is added
  3. washthe resulting solution is washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-dcc3e75750d04b3e984e9e90539535f3
Source dataset
uspto-grants-2008_03
Patent number
US07342032B2

Reaction notes

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