反应详情

The solution of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexane carbonyl]amino]-1-(2-aminophenyl)piperidin-3-ol (4.0 g) obtained in Step 2 in 30 ml of dichloromethane was cooled to 0° C. 2.2 ml of triethylamine and 2.1 ml of 3-chloropivaloyl chloride were added dropwise to the reaction mixture, which was then stirred for about 2 hours at room temperature. 20 ml of iced water was added to the reaction mixture. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was crystallized with ethyl acetate to give 4.1 g of the titled compound.

1. customThe resulting organic layer was dried
2. concentrationconcentrated on sodium sulfate
3. customThe resulting residue was crystallized with ethyl acetate