HCID 10051666, compound → HCID 69315227, compound

HRID 1392429Notes

Reaction equation

HRID 1392429 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[S:31]([CH3:34])(=[O:33])=[O:32])[CH2:21][C:20]2=[O:35])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8].[ClH:36].C(OCC)(=O)C>>[ClH:36].[ClH:36].[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[S:31]([CH3:34])(=[O:33])=[O:32])[CH2:21][C:20]2=[O:35])=[O:17])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)=[O:8]

Participants

3

Reactant 2

HCID 10051666HCID 10051666, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69315227HCID 69315227, compound

Procedure

50 ml of saturated hydrogenchloride-ethyl acetate solution was added to 4-[N-[1-[N-(pyrazin-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-methanesulfonylphenyl)piperidin-3-one (500 mg) obtained in Example 139. The reaction mixture was stirred for 2 hours at room temperature and filtered to give 380 mg of the titled compound as white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-94c52fec88ef41329834aa136c8f5b67
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

Loading…