HCID 10028870, compound → HCID 69310090, compound

HRID 1392430Notes

Reaction equation

HRID 1392430 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[S:31]([CH3:34])(=[O:33])=[O:32])[CH2:21][C:20]2=[O:35])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8].[ClH:36].C(OCC)(=O)C>>[ClH:36].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1([C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[S:31]([CH3:34])(=[O:33])=[O:32])[CH2:21][C:20]2=[O:35])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8]

Participants

3

Reactant 2

HCID 10028870HCID 10028870, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 69310090HCID 69310090, compound

Procedure

50 ml of saturated hydrogenchloride-ethyl acetate solution was added to 4-[N-[1-[N-(pyridin-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-methanesulfonylphenyl)piperidin-3-one (500 mg) obtained in Example 144. The reaction mixture was stirred for 2 hours at room temperature and filtered to give 410 mg of the titled compound as white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-a20af432622d440080a4eefa31c2ac41
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

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