Cyclopropanecarbonyl chloride → HCID 69315173, compound

HRID 1392433Notes

Reaction equation

[F:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][C:9]2([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:29]=[CH:28][C:27](F)=[CH:26][C:25]=4[NH2:31])[CH2:20][CH:19]3[OH:32])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1.[CH:35]1(C(Cl)=O)[CH2:37][CH2:36]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2([C:15]([NH:17][CH:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[NH:31][CH:35]4[CH2:37][CH2:36]4)[CH2:20][C:19]3=[O:32])=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[O:7])=[CH:33][CH:34]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 69310272HCID 69310272, compound

Product 1

HCID 69315173HCID 69315173, compound

Procedure

In accordance with the same procedure as in Example 87, except that 4-[N-[1-[N-(4-fluorobenzoyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol and cyclopropylcarbonyl chloride was used instead of methoxyacetyl chloride in Step 3 thereof, 1.5 g of the titled compound was prepared.

Sources & evidence

ORD record: ord-18c95336607b4b8893efadbb0c17743f
Source dataset: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07342027B2

Reaction notes

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