Hydrogen chloride-ethyl acetate → HCID 69311771, compound

HRID 1392435Notes

Reaction equation

HRID 1392435 reaction equation
[CH3:1][N:2]([CH3:39])[C:3]1[CH:38]=[CH:37][C:6]([C:7]([NH:9][C:10]2([C:16]([NH:18][CH:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[S:32]([CH3:35])(=[O:34])=[O:33])[CH2:21][C:20]3=[O:36])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])=[CH:5][CH:4]=1.[ClH:40].C(OCC)(=O)C>>[ClH:40].[CH3:1][N:2]([CH3:39])[C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][C:10]2([C:16]([NH:18][CH:19]3[CH2:24][CH2:23][N:22]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[S:32]([CH3:35])(=[O:33])=[O:34])[CH2:21][C:20]3=[O:36])=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:8])=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 69311772HCID 69311772, compound

Product 1

HCID 69311771HCID 69311771, compound

Procedure

50 ml of saturated hydrogenchloride-ethyl acetate solution was added to 4-[N-[1-[N-(4-(dimethylamino)benzoyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-methanesulfonylphenyl)piperidin-3-one (500 mg) obtained in Example 171. The reaction mixture was stirred for 2 hours at room temperature and filtered to give 250 mg of the titled compound as white solid.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-416473e966f94999aa736e6900ce958c
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

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