Benzene, 1-bromo-2-(trifluoromethyl)- → HCID 69311880, compound

HRID 1392437Notes

Reaction equation

HRID 1392437 reaction equation
Cl.[CH2:2]([O:9][C:10]([NH:12][C:13]1([C:19]([NH:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[CH:33]=[CH:32][C:31](F)=[CH:30][C:29]=3N)[CH2:24][CH:23]2[OH:36])=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.BrC1C=CC=CC=1[C:44]([F:47])([F:46])[F:45]>>[CH2:2]([O:9][C:10]([NH:12][C:13]1([C:19]([NH:21][CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:44]([F:47])([F:46])[F:45])[CH2:24][C:23]2=[O:36])=[O:20])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]1)=[O:11])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 69315475HCID 69315475, compound

Product 1

HCID 69311880HCID 69311880, compound

Procedure

In accordance with the same procedure as in Example 24, except that 4-[N-[1-[N-(benzyloxycarbonyl)amino]cyclohexanecarbonyl]amino]-1-(4-fluoro-2-aminophenyl)piperidin-3-ol hydrochloride was used instead of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 1-bromo-2-trifluoromethylbenzene was used instead of 1-bromo-4-fluoro-2-trifluoromethylbenzene in Step 1 of Example 24, 228 mg of the titled compound was prepared.

Sources & evidence

ORD record
ord-7b32cb9d0b274a1c91f74a5637ab01be
Source dataset
uspto-grants-2008_03
Patent number
US07342027B2

Reaction notes

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