反应详情

5 g(11.93 mmol, 1 eq) benzhydryl-(4-chloro-2-iodo-phenyl)-amine made in Example 1 was combined with 5 mL DMF. 0.42 g(0.598 mmol, 0.05 eq) dichlorobis-(triphenylphosphine)-palladium, 0.24 g(1.26 mmol, 0.11 eq) copper iodide and 1.8 g (17.58 mmol, 1.5 eq) triethylamine were added. The mixture was stirred at 25 C and 2.72 g (13.65 mmol, 1.14 eq) 2-but-3-ynyl-isoindole-1,3-dione was added in one portion. The mixture warmed to 40 C and was cooled back to room temperature. It became semi-solid after 2 h; an LC showed that at this time the reaction was complete. The mixture was diluted with 10 mL DMF and then 5 mL water was added slowly. Stirring was continued until solids precipitated. The vessel was cooled to 0-5 C and stirred at this temperature for 30 min. The resulting solid was collected by filtration and washed with 10 mL DMF/water 2:1 and 2×10 mL MeOH. The 8.78 g wet solid was dried at 40 C in vacuo for 14 h to obtain 5.55 g product (95%) with 95% purity.

1. additionwas added in one portion
2. temperatureThe mixture warmed to 40 C
3. customafter 2 h
4. customprecipitated
5. temperatureThe vessel was cooled to 0-5 C
6. stirringstirred at this temperature for 30 min
7. filtrationThe resulting solid was collected by filtration
8. washwashed with 10 mL DMF/water 2:1 and 2×10 mL MeOH
9. dry with materialThe 8.78 g wet solid was dried at 40 C in vacuo for 14 h