反应详情

温度

-78 °C

A solution of EtMgBr (35 mL, 35 mmol) in THF (1 M) is added dropwise to a solution of 2-bromo-6-fluoro-benzaldehyde (7 g, 34.5 mmol) in THF at −78° C. The mixture is stirred for 1 hour at −78° C. Saturated NH4Cl is added dropwise to the mixture which is subsequently warmed to room temperature and stirred for 1 hour. The organic layer is separated, extracted with THF (3×100 mL). The combined organic layers are washed with brine, dried and solvent is removed in vacuo. The crude product is purified by flash chromatography (5% EtOAc/hexanes) to obtain 1-(2-bromo-6-fluoro-phenyl)-propan-1-ol.

1. temperatureis subsequently warmed to room temperature
2. stirringstirred for 1 hour
3. customThe organic layer is separated
4. extractionextracted with THF (3×100 mL)
5. washThe combined organic layers are washed with brine
6. customdried
7. customsolvent is removed in vacuo
8. customThe crude product is purified by flash chromatography (5% EtOAc/hexanes)