HCID 91584406, compound → HCID 10098111, compound

HRID 1392708Notes

Reaction equation

HRID 1392708 reaction equation
[C:1]([C:3]1([C:37]([O:39]C(C)(C)C)=[O:38])[CH:5]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N:18]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][N:26]=5)[C:21](=[O:28])[C:20]([C:29]([NH:31][CH:32]5[CH2:34][CH2:33]5)=[O:30])=[CH:19]4)[CH:13]=3)=[CH:8][CH:7]=2)[C:4]1([CH3:36])[CH3:35])#[N:2]>C(Cl)Cl.FC(C(O)=O)(F)F.CSC>[C:1]([C:3]1([C:37]([OH:39])=[O:38])[CH:5]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([N:18]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][N:26]=5)[C:21](=[O:28])[C:20]([C:29]([NH:31][CH:32]5[CH2:34][CH2:33]5)=[O:30])=[CH:19]4)[CH:13]=3)=[CH:8][CH:7]=2)[C:4]1([CH3:36])[CH3:35])#[N:2]

Participants

3

Reactant 1

HCID 91584406HCID 91584406, compound

Product 1

HCID 10098111HCID 10098111, compound

Reagents, catalysts & solvents 1

HCID 131726520HCID 131726520, compoundSolvent

Procedure

The ester from step 3 (1 eq) in CH2Cl2-TFA-DMS (3:2:1, 0.2M) was stirred at rt for 48 h. The volatiles were evaporated, the residue triturated in ether and then isolated by filtration to afford the title compound as a white solid.

Workup

  1. customThe volatiles were evaporated
  2. customthe residue triturated in ether
  3. customisolated by filtration

Sources & evidence

ORD record
ord-f4043f15cc57477a9f9de95999d00780
Source dataset
uspto-grants-2008_03
Patent number
US07342024B2

Reaction notes

Loading…