Chloroacetyl chloride → HCID 13143819, compound

HRID 1392786Notes

Reaction equation

HRID 1392786 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[Cl:9][CH2:10][C:11](Cl)=[O:12]>CN(C)C=O>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1)=[O:12]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 216436-Amino-3-chloropyridazine

Product 1

HCID 13143819HCID 13143819, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Amino-6-chloropyridazine (10.4 g) was dissolved in N,N-dimethylformamide (200 ml), chloroacetyl chloride (7.48 ml) was added to the solution, and the mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate were added to the residue. Solids deposited were collected by filtration and washed with ethyl acetate and water to obtain the title compound (9.39 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure, and ethyl acetate
  2. additiona saturated aqueous solution of sodium hydrogencarbonate were added to the residue
  3. filtrationSolids deposited were collected by filtration
  4. washwashed with ethyl acetate and water

Sources & evidence

ORD record
ord-e2cb73a94a2b4ac682a7aa29925f579c
Source dataset
uspto-grants-2008_03
Patent number
US07342014B2

Reaction notes

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