Hydrochloric Acid → HCID 67056666, compound

HRID 1392801Notes

Reaction equation

HRID 1392801 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([NH:14][C@@H:15]([C@H:22]([NH:25][C:26]([C:28]1[S:29][C:30]3[CH2:31][N:32]([CH3:37])[CH2:33][CH2:34][C:35]=3[N:36]=1)=[O:27])CO)[CH2:16][C:17]([O:19][CH2:20]C)=[O:18])=[O:13])=[CH:6]2>O1CCOCC1>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([NH:14][C@@H:15]1[CH2:16][C:17](=[O:18])[O:19][CH2:20][C@H:22]1[NH:25][C:26]([C:28]1[S:29][C:30]3[CH2:31][N:32]([CH3:37])[CH2:33][CH2:34][C:35]=3[N:36]=1)=[O:27])=[O:13])=[CH:6]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59677009HCID 59677009, compound

Product 1

HCID 67056666HCID 67056666, compoundYield 151.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 4N dioxane solution (20 ml) of hydrochloric acid was added to the compound (0.31 g) obtained in Example 176, and the mixture was heated under reflux for 4 hours. The reaction mixture was concentrated, and the resultant residue was recrystallized from diethyl ether to obtain the title compound (0.23 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. concentrationThe reaction mixture was concentrated
  4. customthe resultant residue was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-c4b31d3950164f0ba11ee0bc6d391d2e
Source dataset
uspto-grants-2008_03
Patent number
US07342014B2

Reaction notes

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