反应详情

温度

120 °C

A round bottom flask is charged with 2-tert-butyl-4-chloro-5-(4-tert-butylbenzyl) thio 3(2H)-pyridazinone (100 mg, 0.27 mmol) and to it is added potassium fluoride (23.4 mg, 0.40 mmol) and 2 ml dimethyl sulfoxide. This is heated to 120° C. for 6 hours. The reaction mixture is then poured into water and extracted with ethyl acetate. This is washed with water and dried. Purification by flash chromatography (silica gel; ethyl acetate/hexanes) gave the above mentioned compound.

1. extractionextracted with ethyl acetate
2. washThis is washed with water
3. customdried
4. customPurification by flash chromatography (silica gel; ethyl acetate/hexanes)
5. customgave the