反应详情

The title compound was prepared from 2-amino-4-(imidazo-[1,2-a]pyridin-3-yl)pyrimidine and 4-bromobenzophenone following the general method of Example 1 using cesium carbonate as the base and tris(dibenzylideneacetone)dipalladium (0) as the palladium source. The crude product was purified by column chromatography on silica gel using chloroform/ethanol, 95:5, as the eluent affording 0.14 g (58% yield) of the title compound as a yellow solid: mp (decomp.) 249-255° C.; MS (TSP) m/z 392 (M+1 ), 1H NMR (400 MHz, DMSO-d6) δ 10.38 (s, 1 H), 10.35 (d, J=6.8 Hz, 1 H), 9.03 (s, 1 H), 8.67 (d, J=5.4 Hz, 1 H), 8.01 (d, J=8.7 Hz, 2 H), 7.98 (m, 1 H), 7.87 (m, 1 H), 7.83 (d, J=8.7 Hz, 2 H), 7.76 (d, J=7.0 Hz; 2 H), 7.69 (m, 1 H), 7.59 (m, 3 H), 7.47 (m, 1 H).

1. customThe crude product was purified by column chromatography on silica gel