反应详情

A 1 M solution of LiAlH4 in dry tetrahydrofuran (12 ml) was added dropwise to a solution of (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)methanone (2 g, 6.6 mmol) in dry tetrahydrofuran (60 ml) under argon atmosphere. The mixture was refluxed overnight. Water was added to the crude, made alkaline with 1 N NaOH and the salts formed was filtered over celite. Extraction with ethyl acetate yielded a solution that was dried with Na2SO4 and concentrated in vacuo to give and oil that was purified by flash chromatography.

1. temperatureThe mixture was refluxed overnight
2. customthe salts formed
3. filtrationwas filtered over celite
4. extractionExtraction with ethyl acetate
5. customyielded a solution that
6. dry with materialwas dried with Na2SO4
7. concentrationconcentrated in vacuo
8. customto give
9. customoil that was purified by flash chromatography