Trifluoroacetic acid → HCID 69219059, compound

HRID 1393079Notes

Reaction equation

HRID 1393079 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH3:14])=[CH:9][C:8]=1[Cl:22])[CH3:2].COC(=O)COC1C=CC(N(C(OC(C)(C)C)=O)C)=CC=1Cl.C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[Cl:22])[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 69217357HCID 69217357, compoundHCID 69220423HCID 69220423, compound

Product 1

HCID 69219059HCID 69219059, compound

Procedure

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-methyl-amino)-2-chloro-phenoxy]-acetic acid ethyl ester containing [4-(tert-butoxycarbonyl-methyl-amino)-2-chloro-phenoxy]-acetic acid methyl ester was TFA deprotected to give (2-chloro-4-methylamino-phenoxy)-acetic acid ethyl ester containing (2-chloro-4-methylamino-phenoxy)-acetic acid methyl ester, MS: 244 (MH+, 1Cl) and 230 (MH+, 1Cl).

Sources & evidence

ORD record
ord-073755b7d33b4318856cf9a4cde0adfd
Source dataset
uspto-grants-2008_03
Patent number
US07345067B2

Reaction notes

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