HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2-Fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 69220064 | HCID 69220064 | — |
| Reactant | HCID 69220603 | HCID 69220603 | — |
| Product | (2-Fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester | HCID 69220211 | — |
Reaction Steps
Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-methyl-amino)-2-fluoro-phenoxy]-acetic acid ethyl ester containing [4-(tert-butoxycarbonyl-methyl-amino)-2-fluoro-phenoxy]-acetic acid methyl ester was deprotected with TFA to give (2-fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester containing (2-fluoro-4-methylamino-phenoxy)-acetic acid methyl ester as an orange oil, MS: 228 (MH+) and 214 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07345067B2 |
| Source dataset | uspto-grants-2008_03 |
| ORD ID | ord-95e09d7dbbe2407690e15f1f231044f2 |
| Source note | uspto-grants-2008_03 |