Trifluoroacetic acid → (2-Fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester

HRID 1393081Notes

Reaction equation

HRID 1393081 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH3:14])=[CH:9][C:8]=1[F:22])[CH3:2].COC(=O)COC1C=CC(N(C(OC(C)(C)C)=O)C)=CC=1F.C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[F:22])[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 69220064HCID 69220064, compoundHCID 69220603HCID 69220603, compound

Product 1

HCID 69220211(2-Fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester

Procedure

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-methyl-amino)-2-fluoro-phenoxy]-acetic acid ethyl ester containing [4-(tert-butoxycarbonyl-methyl-amino)-2-fluoro-phenoxy]-acetic acid methyl ester was deprotected with TFA to give (2-fluoro-4-methylamino-phenoxy)-acetic acid ethyl ester containing (2-fluoro-4-methylamino-phenoxy)-acetic acid methyl ester as an orange oil, MS: 228 (MH+) and 214 (MH+).

Sources & evidence

ORD record
ord-95e09d7dbbe2407690e15f1f231044f2
Source dataset
uspto-grants-2008_03
Patent number
US07345067B2

Reaction notes

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