Trifluoroacetic acid → HCID 67072166, compound

HRID 1393083Notes

Reaction equation

HRID 1393083 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH3:14])=[CH:9][C:8]=1[C:22]([F:25])([F:24])[F:23])[CH3:2].COC(=O)COC1C=CC(N(C(OC(C)(C)C)=O)C)=CC=1C(F)(F)F.C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[C:22]([F:24])([F:25])[F:23])[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 69220060HCID 69220060, compoundHCID 69220227HCID 69220227, compound

Product 1

HCID 67072166HCID 67072166, compound

Procedure

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-methyl-amino)-2-trifluoromethyl-phenoxy]-acetic acid ethyl ester containing [4-(tert-Butoxycarbonyl-methyl-amino)-2-trifluoromethyl-phenoxy]-acetic acid methyl ester was deprotected with TFA to give (4-methylamino-2-trifluoromethyl-phenoxy)-acetic acid ethyl ester containing (4-methylamino-2-trifluoromethyl-phenoxy)-acetic acid methyl ester as light yellow waxy solid, MS: 278 (MH+) and 264 (MH+).

Sources & evidence

ORD record
ord-787749f68f304ee5a9473052963cec3c
Source dataset
uspto-grants-2008_03
Patent number
US07345067B2

Reaction notes

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