Trifluoroacetic acid → HCID 69220327, compound

HRID 1393086Notes

Reaction equation

HRID 1393086 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH3:14])=[CH:9][C:8]=1[O:22][CH3:23])[CH3:2].COC(=O)COC1C=CC(N(C(OC(C)(C)C)=O)C)=CC=1OC.C(O)(C(F)(F)F)=O>>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[O:22][CH3:23])[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 69217800HCID 69217800, compoundHCID 69220402HCID 69220402, compound

Product 1

HCID 69220327HCID 69220327, compound

Procedure

Analogously, to example 1.4, crude [4-(tert-butoxycarbonyl-methyl-amino)-2-methoxy-phenoxy]-acetic acid ethyl ester containing [4-(tert-butoxycarbonyl-methyl-amino)-2-methoxy-phenoxy]-acetic acid methyl ester was deprotected with TFA to give (2-methoxy-4-methylamino-phenoxy)-acetic acid ethyl ester containing (2-methoxy-4-methylamino-phenoxy)-acetic acid methyl ester as a brown oil, MS: 240 (MH+) and 226 (MH+).

Sources & evidence

ORD record
ord-40b799f581a448ab88bc59fc4e2d7c7c
Source dataset
uspto-grants-2008_03
Patent number
US07345067B2

Reaction notes

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