2-(3-Methoxy-prop-1-ynyl)-phenoxy-acetic acid ethyl ester → HCID 67072081, compound

HRID 1393094Notes

Reaction equation

HRID 1393094 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[C:14][CH2:15][O:16][CH3:17])[CH3:2]>CCOC(C)=O.[Pd]>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH3:2]

Participants

4

Reactant 1

HCID 670722722-(3-Methoxy-prop-1-ynyl)-phenoxy-acetic acid ethyl ester

Product 1

HCID 67072081HCID 67072081, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

9.54 g (38.4 mmol) of the above prepared [2-(3-methoxy-prop-1-ynyl)-phenoxy]-acetic acid ethyl ester was hydrogenated at RT in 130 ml of EtOAc over 2.39 g of Pd/C (10%) under 1 atm. of H2-pressure. After 2 h at ambient temperature, the reaction mixture was filtrated over Celite and carefully rinsed with EtOAc. Evaporation of the solvent left finally 9.39 g of the title compound as colorless oil, MS: 252.2 (M)+.

Workup

  1. filtrationthe reaction mixture was filtrated over Celite
  2. washcarefully rinsed with EtOAc
  3. customEvaporation of the solvent
  4. waitleft finally 9.39 g of the title compound as colorless oil, MS

Sources & evidence

ORD record
ord-fa55ada25668461384159b2ef9a05ec7
Source dataset
uspto-grants-2008_03
Patent number
US07345067B2

Reaction notes

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