Hydrochloric Acid → 3-[N-(2-Cyclohexylethyl)amino]propionamide hydrochloride

HRID 1393142Notes

Reaction equation

HRID 1393142 reaction equation
[ClH:1].C(OC([N:9]([CH2:18][CH2:19][C:20]([NH2:22])=[O:21])[CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[CH:12]1([CH2:11][CH2:10][NH:9][CH2:18][CH2:19][C:20]([NH2:22])=[O:21])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 121366253-[N-(t-butoxycarbonyl)-N-(2-cyclohexylethyl)amino]propionamide

Product 1

HCID 219741893-[N-(2-Cyclohexylethyl)amino]propionamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Next, a 4 N solution of hydrogen chloride in 1,4-dioxane (3.1 ml) was added to 3-[N-(t-Butoxycarbonyl)-N-(2-cyclohexylethyl)amino]propionamide (0.37 g, 1.2 mmol), and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, diisopropyl ether was added to the resulting solid, and the solid was filtered off to give 0.30 g (quantitatively) of the titled compound as colorless crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure, diisopropyl ether
  2. additionwas added to the resulting solid
  3. filtrationthe solid was filtered off

Sources & evidence

ORD record
ord-35adba935166477d97010516cc525c09
Source dataset
uspto-grants-2008_03
Patent number
US07345064B2

Reaction notes

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