反应详情

温度

17.5 °C

124 g (0.228 moles) of 2-butyl-3-{2′-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-biphenyl-4-ylmethyl}-1,3-diaza-spiro[4.4]non-1-en-4-one are dissolved in 500 ml of toluene and 900 ml of 37% aqueous hydrochloric acid are added thereto under stirring at a temperature of 15-20° C. The mixture is stirred for a further 4 h, then the aqueous phase is separated and washed twice with 250 ml of toluene. The aqueous phase is poured into a solution of 125 g of sodium acetate in water, the formed precipitate is filtered, thoroughly washed with water and dried under vacuum at 70° C., thereby obtaining 77 g of irbesartan.

1. stirringThe mixture is stirred for a further 4 h
2. customthe aqueous phase is separated
3. washwashed twice with 250 ml of toluene
4. additionThe aqueous phase is poured into a solution of 125 g of sodium acetate in water
5. filtrationthe formed precipitate is filtered
6. washthoroughly washed with water
7. customdried under vacuum at 70° C.