Sodium Hydroxide → HCID 45487094, compound

HRID 1393236Notes

Reaction equation

HRID 1393236 reaction equation
[OH-].[Na+].COC([N:7]1[C:17]2[CH2:16][CH:15]3[N:18]([S:19]([C:22]4[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=4)(=[O:21])=[O:20])[CH:11]([CH2:12][N:13]([C:29]([O:31][CH3:32])=[O:30])[CH2:14]3)[C:10]=2[CH:9]=[N:8]1)=O>C1COCC1.C(Cl)Cl.O>[CH3:32][O:31][C:29]([N:13]1[CH2:12][CH:11]2[N:18]([S:19]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)(=[O:21])=[O:20])[CH:15]([CH2:16][C:17]3[NH:7][N:8]=[CH:9][C:10]=32)[CH2:14]1)=[O:30]

Participants

6

Reactant 2

HCID 14798Sodium HydroxideHCID 5967948412-(4-Chloro-benzenesulfonyl)-4,5,10,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene-5,10-dicarboxylic acid dimethyl ester

Product 1

HCID 45487094HCID 45487094, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

Aqueous sodium hydroxide (3 N, 0.39 mL, 1.18 mmol) was added to a stirring solution of 12-(4-chloro-benzenesulfonyl)-4,5,10,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene-5,10-dicarboxylic acid dimethyl ester (270 mg, 0.594 mmol) in THF (1 mL). The reaction mixture was stirred for 3 h at room temperature and subsequently diluted with methylene chloride (10 mL) and water (5 mL). The phases were separated and the aqueous layer was extracted with methylene chloride (2×5 mL). The organic extracts were combined, dried (Na2SO4), filtered, concentrated and purified by preparative HPLC to give 12-(4-chloro-benzenesulfonyl)-4,5,10,12-tetraaza-tricyclo[6.3.1.02,6]dodeca-2(6),3-diene-10-carboxylic acid methyl ester as a white solid. Retention time (min)=1.435, method [1], MS(ESI) 397.13 (M+H); 1H NMR (300 MHz, CDCl3) δ 7.60 (d, J=8.2 Hz, 2H), 7.50 (s, 1H), 7.35 (d, J=8.2 Hz, 2H), 5.21 (s, 1H), 4.41 (s, 1H), 4.19-4.01 (m, 1H), 3.90 (d, J=13.2 Hz, 1H), 3.60-3.40 (m, 3H), 3.35-3.14 (m, 2H), 2.85-2.80 (m, 1H), 2.71 (d, J=17.6 Hz, 1H).

Workup

  1. customThe phases were separated
  2. extractionthe aqueous layer was extracted with methylene chloride (2×5 mL)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated
  6. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-905c672c2ee145228558e126d7b52dee
Source dataset
uspto-grants-2008_03
Patent number
US07345056B2

Reaction notes

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