Aluminium lithium hydride → HCID 23033855, compound

HRID 1393356Notes

Reaction equation

HRID 1393356 reaction equation
[CH3:1][N:2]([CH3:21])[C:3]1[N:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][N:2]([CH3:21])[C:3]1[N:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([CH2:18][OH:19])=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 23033935HCID 23033935, compound

Product 1

HCID 23033855HCID 23033855, compoundYield 54%

Procedure

Methyl ester of 2-(2-dimethylaminopyrimidin-5-yl)benzoxazole-7-carboxylic acid (480 mg, 1.61 mmol) was reduced by using lithium aluminium hydride as in Preparation 2-3) to give 2-(2-dimethylamino-pyrimidin-5-yl)benzoxazole-7-methanol (234 mg, 54%) as yellow crystals.

Workup

  1. customas in Preparation 2-3)

Sources & evidence

ORD record
ord-40417fc9df8b435992afd23479810145
Source dataset
uspto-grants-2008_03
Patent number
US07345068B2

Reaction notes

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