HCID 86598325, compound → HCID 69320224, compound

HRID 1393380Notes

Reaction equation

HRID 1393380 reaction equation
C(OC(=O)[C@H](CC1C=CC=C(OC2C=CC(O)=CC=2)C=1)NC(=O)C(F)(F)F)C.C([O:31][C:32](=[O:64])[C@H:33]([CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[C:44]([O:48][C:49]2[CH:54]=[CH:53][C:52]([O:55][C:56]3[CH:61]=[CH:60][C:59]([O:62]C)=[CH:58][CH:57]=3)=[CH:51][CH:50]=2)[CH:43]=1)[NH:34]C(=O)C(F)(F)F)C>>[OH:62][C:59]1[CH:58]=[CH:57][C:56]([O:55][C:52]2[CH:53]=[CH:54][C:49]([O:48][C:44]3[CH:43]=[C:42]([CH:47]=[CH:46][CH:45]=3)[CH2:41][C@@H:33]([C:32]([OH:64])=[O:31])[NH2:34])=[CH:50][CH:51]=2)=[CH:61][CH:60]=1

Participants

3

Reactant 2

HCID 86598325HCID 86598325, compoundHCID 86598326HCID 86598326, compound2×

Product 1

HCID 69320224HCID 69320224, compound

Procedure

In a similar manner to Example 49-1), 3-[4-(4-hydroxyphenoxy)-phenoxy]-L-phenylalanine was synthesized by deprotecting by a conventional method from N-trifluoroacetyl-3-(4-hydroxyphenoxy)-L-phenylalanine ethyl ester via N-trifluoroacetyl-3-[4-(4-methoxyphenoxy)phenoxy]-L-phenylalanine ethyl ester. N-Trifluoroacetyl-3-[4-(4-methoxyphenoxy)phenoxy]-L-phenylalanine ethyl ester: m.p.: 67-71° C.; IR (Nujol): 3324, 1745, 1707, 1559, 1507, 1501 cm−1; APCI-MS m/z: 504 [M+H]+.

Sources & evidence

ORD record
ord-44db2a5aa00741b38bc00d51c3f0bfcc
Source dataset
uspto-grants-2008_03
Patent number
US07345068B2

Reaction notes

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