Triethylamine → HCID 21938103, compound

HRID 1393537Notes

Reaction equation

HRID 1393537 reaction equation
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:35][N:36]=[C:37]=[O:38]>ClCCl>[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][C:37](=[O:38])[NH:36][CH3:35])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 8471Triethylamine2×HCID 12228Methyl Isocyanate2×HCID 21938176HCID 21938176, compound

Product 1

HCID 21938103HCID 21938103, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

100 mg of 4-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]butan-1-ol was dissolved in 4 ml of dichloromethane, mixed with 0.1 ml of triethylamine and 20 mg of methyl isocyanate and stirred for 15 hours. Another 0.1 ml of triethylamine and 20 mg of methyl isocyanate were added, allowed to stir for 20 hours, and then concentrated by evaporation in a vacuum. The residue was purified using chromatography on silica gel.

Workup

  1. stirringto stir for 20 hours
  2. concentrationconcentrated by evaporation in a vacuum
  3. customThe residue was purified

Sources & evidence

ORD record
ord-103dc1dea9eb4be5b1aef562bec8c91b
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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