HCID 10300899, compound → HCID 10136601, compound

HRID 1393540Notes

Reaction equation

HRID 1393540 reaction equation
C1(C[O:8][NH:9][C:10](=[O:38])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]3[N:24]=[C:23]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[N:22]([C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:21]=3[CH:37]=2)C=CC=CC=1>C(O)C.[Pd]>[OH:8][NH:9][C:10](=[O:38])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]1[CH:18]=[CH:19][C:20]2[N:24]=[C:23]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:22]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:21]=2[CH:37]=1

Participants

4

Reactant 1

HCID 10300899HCID 10300899, compound

Product 1

HCID 10136601HCID 10136601, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

23 mg of N-(phenylmethoxy)-6-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]hexanamide was dissolved in 4 ml of ethanol, mixed with 15 mg of palladium on carbon (10%) and stirred under a hydrogen atmosphere for 3 hours. After catalyst was separated out, it was concentrated by evaporation in a vacuum, and the residue was crystallized from diethyl ether.

Workup

  1. customAfter catalyst was separated out
  2. concentrationit was concentrated by evaporation in a vacuum
  3. customthe residue was crystallized from diethyl ether

Sources & evidence

ORD record
ord-97b3d7cc11374dc4b2b78dad5e66cbcd
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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