HCID 67366246, compound → HCID 67364124, compound

HRID 1393560Notes

Reaction equation

HRID 1393560 reaction equation
[CH3:1][O:2][C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:15]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:14]=2[C:30]=1[N+:31]([O-])=O>C(O)C.[Ni]>[CH3:1][O:2][C:3](=[O:34])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:15]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:14]=2[C:30]=1[NH2:31]

Participants

4

Reactant 1

HCID 67366246HCID 67366246, compound

Product 1

HCID 67364124HCID 67364124, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

340 mg of 6-[(1,2-diphenyl-7-nitro-1H-benzimidazol-6-yl)oxy]hexanoic acid methyl ester was hydrogenated in ethanol with Raney nickel in an autoclave at 50° C. and at normal pressure. After hydrogen absorption ended, catalyst was filtered out and concentrated by evaporation in a vacuum.

Workup

  1. customAfter hydrogen absorption
  2. filtrationcatalyst was filtered out
  3. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-6a30ebbb262449b387d0b77d14dcc449
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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