HCID 21938145, compound → HCID 21938042, compound

HRID 1393572Notes

Reaction equation

HRID 1393572 reaction equation
C([O:5][C:6](=[O:33])[CH2:7][O:8][CH2:9][CH2:10][O:11][C:12]1[CH:13]=[CH:14][C:15]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[N:17]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:16]=2[CH:32]=1)(C)(C)C>FC(F)(F)C(O)=O.O>[C:26]1([N:17]2[C:16]3[CH:32]=[C:12]([O:11][CH2:10][CH2:9][O:8][CH2:7][C:6]([OH:33])=[O:5])[CH:13]=[CH:14][C:15]=3[N:19]=[C:18]2[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

4

Reactant 1

HCID 21938145HCID 21938145, compound

Product 1

HCID 21938042HCID 21938042, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

50 mg of 2-[2-[(1,2-diphenyl-1H-benzimidazol-6-yl)oxy]ethoxy]acetic acid-tert-butyl ester was dissolved in 0.5 ml of trifluoroacetic acid and stirred for 48 hours. Then, it was diluted with water and extracted three times with ethyl acetate. The combined organic phases were washed with saturated sodium chloride solution, dried on sodium sulfate and concentrated by evaporation in a vacuum. The residue was chromatographed on silica gel.

Workup

  1. extractionextracted three times with ethyl acetate
  2. washThe combined organic phases were washed with saturated sodium chloride solution
  3. customdried on sodium sulfate
  4. concentrationconcentrated by evaporation in a vacuum
  5. customThe residue was chromatographed on silica gel

Sources & evidence

ORD record
ord-1a4e92eb315d422f90ecda916ac19307
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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