Hydrogen Bromide → HCID 21938168, compound

HRID 1393582Notes

Reaction equation

HRID 1393582 reaction equation
[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([O:24]C)[CH:3]=1.Br>C(O)(=O)C>[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([OH:24])[CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21938149HCID 21938149, compound

Product 1

HCID 21938168HCID 21938168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.2 g of 4-bromo-6-methoxy-1-(4-methylphenyl)-2-phenyl-1H-benzimidazole, 6 ml of acetic acid and 6 ml of aqueous hydrobromic acid (62%) are boiled for 5.5 hours. Then, it is precipitated with water, and the precipitate is suctioned off. The latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution. After the organic phase was washed with water, it was concentrated by evaporation.

Workup

  1. customThen, it is precipitated with water
  2. additionThe latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution
  3. washAfter the organic phase was washed with water, it
  4. concentrationwas concentrated by evaporation

Sources & evidence

ORD record
ord-5c242c31640f41b58b6e7da226327598
Source dataset
uspto-grants-2008_03
Patent number
US07345075B2

Reaction notes

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