3-Cyanopyridine → Nicotinamide

HRID 1393622Notes

Reaction equation

HRID 1393622 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[OH2:9]>O=[Mn]=O>[C:1]([NH2:2])(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[N:5][CH:4]=1

Participants

4

Reactant 2

HCID 793-CyanopyridineHCID 962Water

Product 1

HCID 936NicotinamideYield 91.6%

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Conditions

Temperature
100 °C

Procedure

0.096 mole 3-cyanopyridine was dissolved in 4.55 mole of water and 0.0115 mole of MnO2 prepared by above method was added to this. The mixture was refluxed at 100° C. for 13.5 hrs. The reaction mixture as cooled and filtered. The filtrate was evaporated to dryness to get solid nicotinamide 0.0879 mole. Yield of nicotinamide was 91.56 mole %.

Workup

  1. additionwas added to this
  2. temperatureThe reaction mixture as cooled
  3. filtrationfiltered
  4. customThe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-4ef3a9517e7f4773882eb7f4e425e164
Source dataset
uspto-grants-2008_03
Patent number
US07345176B2

Reaction notes

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