p-Toluenesulfonic acid monohydrate → HCID 59680443, compound

Temperature

60 °C

(2,5-dichloro-4-nitrophenyl)acetic acid (22) (Valerie K. Chamberlain and R. L. Wain. Ann. appl. Biol. (1971), 69, 65-72.) (500 mg, 2.0 mmol) was dissolved in ethanol (10 ml), and after adding p-toluenesulfonic acid monohydrate (50 mg, 0.26.mmol), the mixture was stirred at 60° C. for 2 hours. The reaction mixture was cooled to room temperature, and concentrated and exsiccated under reduced pressure. To the resulting residue was added a saturated solution of sodiumbicarbonate (30 ml), and the mixture was extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The resulting residue was purified by column chromatography using silica gel, and from the eluate of chloroform was obtained the title compound (505 mg, 91%) as a pale yellow crystal powder.

1. temperatureThe reaction mixture was cooled to room temperature
2. concentrationconcentrated
3. additionTo the resulting residue was added a saturated solution of sodiumbicarbonate (30 ml)
4. extractionthe mixture was extracted with chloroform
5. dry with materialThe extract was dried over anhydrous sodium sulfate
6. distillationthe solvent was distilled off under reduced pressure
7. customThe resulting residue was purified by column chromatography

ORD record

ord-48f9cd635b954a22baa3f27685ca4082

Source dataset

uspto-grants-2008_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07345179B2