Trifluoroacetic acid → HCID 23557283, compound

HRID 1393625Notes

Reaction equation

HRID 1393625 reaction equation
[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:17]([O:19]C(C)(C)C)=[O:18])[C:10]([O:12]C(C)(C)C)=[O:11].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:24])/[CH:4]=[CH:5]/[CH:6]=[CH:7]/[CH2:8][CH:9]([C:10]([OH:12])=[O:11])[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23557315HCID 23557315, compound

Product 1

HCID 23557283HCID 23557283, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 40 (200 mg, 0.59 mmol) in CH2Cl2 (10 mL) was added TFA (1 mL). The reaction was allowed to proceed overnight. Volatiles were removed under reduced pressure to leave 41 as a white solid (112 mg, 0.49 mmol, 83%). 1H-NMR (CD3OD, 400 MHz) δ 7.11 (dd, 1H), 6.33 (dd, 1H), 6.16 (m, 1H), 5.81 (d, 1H), 3.76 (s, 3H), 3.15 (t, 1H), 2.70 (t, 2H).

Workup

  1. customVolatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-38e8407c7cb94dd7996b3fcf87eef21e
Source dataset
uspto-grants-2008_03
Patent number
US07345174B2

Reaction notes

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