1,4-Dioxane → HCID 20038701, compound

3-t-Butyl thiazolidine-3,4-dicarboxylate (2.0 g) was dissolved in tetrahydrofuran (10 ml), and N,N′-carbonyl diimidazole (1.4 g) was added thereto with ice-cooling. The mixture was warmed to room temperature and stirred for 6 hours. 1,4-Dioxane (10 ml) was added thereto, and the mixture was added dropwise to 28% ammonia water (40 ml) cooled on an ice bath. The mixture was warmed to room temperature and stirred for 20 hours. The reaction solution was extracted with ethyl acetate (60 ml). The organic phase was washed with a saturated saline solution and dried over sodium sulfate anhydrous. The product was concentrated under reduced pressure to give t-butyl 4-carbamoylthiazolidine-3-carboxylate (1.6 g, Y.:81%).

1. temperaturewith ice-cooling
2. temperaturecooled on an ice bath
3. temperatureThe mixture was warmed to room temperature
4. stirringstirred for 20 hours
5. extractionThe reaction solution was extracted with ethyl acetate (60 ml)
6. washThe organic phase was washed with a saturated saline solution
7. dry with materialdried over sodium sulfate anhydrous
8. concentrationThe product was concentrated under reduced pressure

ORD record

ord-f8213438ade54b82b880066a0d1e47dd

Source dataset

uspto-grants-2008_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07345180B2