Chloroacetyl chloride → HCID 45080717, compound

HRID 1393641Notes

Reaction equation

HRID 1393641 reaction equation
[NH:1]1[CH2:4][CH2:3][CH:2]1[C:5]([NH2:7])=O.[Cl:8][CH2:9][C:10](Cl)=[O:11]>>[Cl:8][CH2:9][C:10]([N:1]1[CH2:4][CH2:3][C@H:2]1[C:5]#[N:7])=[O:11]

Participants

3

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 14751894AZETIDINE-2-CARBOXAMIDE

Product 1

HCID 45080717HCID 45080717, compoundYield 44%

Procedure

In a similar procedure as employed in the Intermediate Example 1, the azetidine-2-carboxylic acid amide (161 mg) obtained above was reacted with chloroacetyl chloride (200 mg) and then subjected to dehydration reaction to give the title compound (112 mg, Y.:44%).

Workup

  1. customsubjected to dehydration reaction

Sources & evidence

ORD record
ord-d47eb158b0e947ca87ffc9ebf6273010
Source dataset
uspto-grants-2008_03
Patent number
US07345180B2

Reaction notes

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