反应详情

Hydrazine monohydrate (0.49 ml) was added to a solution of the thus obtained 4-methoxy-3-oxobutyronitrile (1.14 g) in ethanol (50 ml), and refluxed for 17 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography (eluting solvent; dichloromethane:methanol 50:1) to give 5-methoxymethyl-2H-pyrazol-3-ylamine (684 mg, Y.:53%).

1. temperaturerefluxed for 17 hours
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by column chromatography (eluting solvent; dichloromethane:methanol 50:1)