反应详情

5 N Sodium hydroxide solution (0.1 ml) was added to a solution of the thus obtained ethyl 2-hydroxymethylpyrazolo[1,5-a]pyrimidine-6-carboxylate (19 mg) in tetrahydrofuran (1 ml), and stirred for 17 hours at room temperature. After water was added, the reaction mixture was washed with ethyl acetate. The aqueous phase was acidified by 2 N hydrochloric acid, extracted with ethyl acetate and dried over sodium sulfate anhydrous. The resulting product was concentrated under reduced pressure, and the residue was dissolved in hot ethyl acetate and then filtered. The filtrate was concentrated under reduced pressure to give the title compound (11 mg, Y.:65%).

1. washthe reaction mixture was washed with ethyl acetate
2. extractionextracted with ethyl acetate
3. dry with materialdried over sodium sulfate anhydrous
4. concentrationThe resulting product was concentrated under reduced pressure
5. dissolutionthe residue was dissolved in hot ethyl acetate
6. filtrationfiltered
7. concentrationThe filtrate was concentrated under reduced pressure