HCID 23091904, compound → 1-(2,2-Dimethylpropionyl)-1H-indole-5-carboxylic acid

HRID 1393679Notes

Reaction equation

HRID 1393679 reaction equation
[CH3:1][C:2]([CH3:25])([CH3:24])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]CC3C=CC=CC=3)=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)=[O:4].[H][H]>C(O)C.[Pd]>[CH3:1][C:2]([CH3:25])([CH3:24])[C:3]([N:5]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1)=[O:4]

Participants

5

Reactant 2

HCID 23091904HCID 23091904, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 230919501-(2,2-Dimethylpropionyl)-1H-indole-5-carboxylic acidYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The benzyl 1-(2,2-dimethylpropionyl)-1H-indole-5-carboxylate (220 mg) obtained above was dissolved in ethanol, and 5% palladium on carbon (44 mg) was added thereto and stirred overnight at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (140 mg, Y.:86%).

Workup

  1. customInsoluble matter was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fc52fc0792604ff2b7098bed61d5828b
Source dataset
uspto-grants-2008_03
Patent number
US07345180B2

Reaction notes

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